Immunotherapy is a kind of treatment that focuses on increasing the body own immune reply against cancer tumors.This type of treatment has developed more general over the past few years, and investigators have made it important to know better how cancer cells and specialized immune cells interact with each other
In a new study, a side of investigators from the Abramson Cancer Center of the University of Pennsylvania in Philadelphia, PA has examined how to stimulate macrophages to attack cancer cells.
Priming immune cells against cancerThe investigators clarify that just blocking the eat me signs that the cancer tumors convey does not always lead the macrophages to base their attack.For this reason, using a mouse perfect, the team verified out a method of activating and these immune cells to attack against the tumors.It turns out macrophages need to be aware before they can go to work, which clarifies why solid tumors may resist action with CD47 inhibitors alone; notes the study’s senior author Dr. Gregory Beatty.
A shift in metabolism is needed to comprehend why this occurred, Dr. Beatty and team analyzed the metabolism of the macrophages after activation. They saw that these immune cells metabolic activity had shifted, and the macrophages were trusting on both glutamine (an amino acid) and glucose (a simple sugar) for their vigor supplies. Cancer does not shrink without the help of macrophages and macrophages need the right fuel to eat cancer cells and shrink tumors notes Dr. Jason Mingen Liu, the studys lead author.
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